solubility of naproxen in polyethylene glycol 200 + water mixtures at various temperatures

Authors

vahid panahi-azar liver and gastrointestinal diseases research center, tabriz university of medical sciences, tabriz, iran

shahla soltanpour faculty of pharmacy, zanjan university of medical sciences, zanjan 45139, iran

fleming martinze grupo de investigaciones farmacéutico-fisicoquímicas, departamento de farmacia, universidad nacional de colombia, a.a. 14490, bogotá d.c., colombia

abolghasem jouyban faculty of pharmacy

abstract

the solubility of naproxen in binary mixtures of polyethylene glycol 200 (peg 200) + water at the temperature range from 298.0 k to 318.0 k were reported. the combinations of jouyban-acree model + van’t hoff and jouyban-acree model + partial solubility parameters were used to predict the solubility of naproxen in peg 200 + water mixtures at different temperatures. combination of jouyban-acree model with van’t hoff equation can be used to predict solubility in peg 200 + water with only four solubility data in mono-solvents. theobtained solubility calculation errors vary from ~ 17 % up to 35 % depend on the number of required input data.non-linear enthalpy-entropy compensation was found for naproxen in the investigated solvent system and the jouyban−acree model provides reasonably accurate mathematical descriptions of the thermodynamic data of naproxen in the investigated binary solvent systems.

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Journal title:

iranian journal of pharmaceutical research

جلد ۱۴، شماره ۴، صفحات ۱۰۴۱-۱۰۵۰

Keywords

thermodynamic analysis solubility naproxen jouyban–acree model

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